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1.
ssrn; 2021.
Preprint in English | PREPRINT-SSRN | ID: ppzbmed-10.2139.ssrn.3814761

ABSTRACT

Background: The long-term effects of COVID-19 still remain to be explored. The purpose of this study is to describe the clinical complications of SARS-CoV-2 infection at one year after acute disease, either in inpatients and outpatients, and to explore associated risk factors, in particular disease severity during the acute phase.Methods: This study is part of a large cohort study of COVID+ patients. Seven-hundred seventeen patients from the metropolitan area of Milan in Lombardia (Italy) who had been referred for tele-monitoring after a confirmed or plausible SARS-CoV-2 infection between February and May 2020 were evaluated with a semi-structured phone interview between February and March 2021, regardless of the severity of the disease during the acute phase. In the phone interview performed by trained medical staff we looked for clinical complications in the following domains: respiratory disorders, fatigue and weakness, muscle and joint pain, movement impairments, neurological and cognitive impairments, sensory alterations, sleep disorders, and gastrointestinal symptoms. Patients were asked if symptoms were present before the SARS-CoV-2 infection, and if the symptom was present at the current time.Interpretation: At 12-months after acute infection, COVID-19 survivors were still suffering of symptoms identified at shorter follow-up including fatigue, pain and sleep disorders among the most frequent. A more severe impairment in the acute phase did not seem to predict more severe complications, further supporting the unpredictability of such consequences. These data need to be considered and compared with other studies from other countries on COVID-19 survivors and have to be taken into account to plan public health interventions.Funding: Fondazione Invernizzi and Regional Operational Programme (ERDF ROP) 2014-2020Declaration of Interest: None to declare. Ethical Approval: This study was approved by the Ethics Commission of the University of Milan, (Ethics Commission number: 126/20). Written informed consent was obtained from allparticipants.


Subject(s)
COVID-19 , Respiratory Tract Infections , Gastrointestinal Diseases , Muscle Weakness
2.
researchsquare; 2020.
Preprint in English | PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-108215.v1

ABSTRACT

Background:  The rapid diffusion of Coronavirus disease (Covid-19) in Northern Italy led Italian government to dictate national lockdown since March 12th 2020 to May 5th 2020. Aim of the study is to analyze the differences in the number of pediatric patients’ admission to the Emergency Room (ER) and in the type and causes of injury. Methods: The pediatric population was divided in a Pandemic group (PG) and Non-Pandemic group (NP). Sex, age, triage color-code at admission, declared cause of trauma and presence of symptoms related to COVID-19 infection, discharge diagnosis and discharge modes were investigated. Results: The Lockdown period led to a reduction of 87.0% in the ER admissions with a particular decrease in patients older than 12 years old from 41.8% in NG to 22.3% in PG. Moreover, a trend towards more severe codes was observed in the PG and the diagnosis of fracture was less frequent in NG (p<0,0001) and injuries at home were more frequent (34.8% compared to 6.8% in NG).Conclusions: A significant decrease in the ER attendances in our Trauma Hub center was reported after the outbreak of Covid-19 pandemic. Furthermore, a shift in the cause and type of injury undoubtedly was observed and only the most serious traumas sought the medical care with an higher percentage of severe triage codes and fractures.Level of evidence: III


Subject(s)
Coronavirus Infections , Chemical and Drug Induced Liver Injury , Wounds and Injuries , COVID-19 , Fractures, Bone
3.
researchsquare; 2020.
Preprint in English | PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-66890.v1

ABSTRACT

Background:  The rapid diffusion of Coronavirus disease (Covid-19) in Northern Italy led Italian government to dictate national lockdown since March 12th 2020 to May 5th 2020. Aim of the study is to analyze the differences in the number of pediatric patients’ admission to the Emergency Room (ER) and in the type and causes of injury. Methods: The pediatric population was divided in a Pandemic group (PG) and Non-Pandemic group (NP). Sex, age, triage color-code at admission, declared cause of trauma and presence of symptoms related to COVID-19 infection, discharge diagnosis and discharge modes were investigated. Results: The Lockdown period led to a reduction of 87.0% in the ER admissions with a particular decrease in patients older than 12 years old from 41.8% in NG to 22.3% in PG. Moreover, a trend towards more severe codes was observed in the PG and the diagnosis of fracture was less frequent in NG (p<0,0001) and injuries at home were more frequent (34.8% compared to 6.8% in NG).Conclusions: A significant decrease in the ER attendances in our Trauma Hub center was reported after the outbreak of Covid-19 pandemic. Furthermore, a shift in the cause and type of injury undoubtedly was observed and only the most serious traumas sought the medical care with an higher percentage of severe triage codes and fractures.Level of evidence: III


Subject(s)
Coronavirus Infections , Chemical and Drug Induced Liver Injury , Wounds and Injuries , COVID-19 , Fractures, Bone
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